On Apokilips though a villain known as Darkseid is plotting to release the villains of Earth and cause an all out war. While the JLA Prepares themselves for this their enemies begin to appear in different parts of the World.
At Belle Reve Lex Luthor and Brainiac attempt to keep in contact with their allies who are at Arkham, Blackgate and Stryker's Island,others are in hiding though. As they are doing this on Apokilips a villains known as Darkseid is breaking villains out of prisons across the World(s). The JLA then prepares themselves for this attack. As batman is coming to space he is assaulted by the Sinestro Corps. When the New Gods save him. At the watchtower Batman, The New Gods, Robin, Green Lantern, Kilowog, Superman, Wonder Woman, Aquaman, Flash, Cyborg, Martian Manhunter and Hawkman are attempting to contain the breakouts. Soon they find the watchtower under attack by General Zod and his army.After containing them the heroes go to Earth where Starro is attacking Gotham. Batman defeats Starro, when the escaped villains along with Darkseid and his elite attack.
There are over 400 playable characters in game.